Prof. Bertil Hille
Bertil Hille is a professor in the Department of Physiology and Biophysics at the University of Washington. He is particularly well known for his research and expertise on cell signalling by ion channels. Bertil Hille pioneered the concept of ion channels as membrane proteins forming gated aqueous pores (with Clay Armstrong). He showed that Na+ and K+ channels of axons can be distinguished by drugs such as tetrodotoxin and tetraethylammonium ion, and that their ionic selectivity can be understood by a limiting pore size, the selectivity filter, and by movements of ions through a series of saturable sites. He showed that local anesthetics enter Na+ channels in a state-dependent manner.
In 1999 he received the Albert Lasker Award for Basic Medical Research.